中華科技大學

林娟娟 副教授

學歷： 美國Rutgers University食品科學博士
分機：(02)2782-1862 轉274　再轉109
教師研究室：至正樓1樓(J109R)
Email： cclin@cc.cust.edu.tw
主要專長：食品科學、生物化學、天然物藥理、中草藥研發

主要學歷　

  • 美國Rutgers University食品科學博士
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    相關經歷　

  • 中華科技大學食品科學系系主任
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  • 財團法人醫藥工業技術發展中心科研處藥物研究組副研究員
  • 國立臺灣大學食品科技所博士後研究員
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  • 國立臺灣大學化學系助教
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    研究成果

    研究主題
    • 中草藥抗氧化及雌激素成分之篩選及分離技術開發
    • 異黃酮類化合物對癌細胞增生之分子作用機制的研究
    • 不同萃取方式增進含多酚類之中草藥萃取物於微乳膠系統之生體可用率
    • 具保健功效水膠晶球應用於新穎性食品開發

    期刊論文
    • Genistein suppresses the proliferation of telomerase- negative cells
    • Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers
    • Preparation of curcumin microemulsions with food-grade soybean oil/lecithin and their cytotoxicity on the HepG2 cell line
    • fermented citrus peels and physical properties of citrus peel-added doughs for bread making
    • Extraction of resveratrol from polygonum cuspidatum with magnetic orcinol-imprinted poly(ethylene-co-vinyl alcohol) composite particles and their in vitro suppression of human osteogenic sarcoma (HOS) cell line
    • Comparison of the antioxidant and transmembrane permeative activities of the different polygonum cuspidatum extracts in phospholipid-based microemulsions
    • Comparison of the antioxidant and transmembrane permeative activities of the different polygonum cuspidatum extracts in phospholipid-based microemulsions
    • Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, b-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin
    • Dibenzoylmethane Altered Adipose Mass, Serum Lipid and Sex Steroid Hormone in Female Mice
    • Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, b-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin
    • Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions
    • Enhancement of the encapsulation and transmembrane permeation of isoflavone-containing red clover extracts in phospholipid-based microemulsions using different extraction processes
    • Determination of the differential estrogenicity of isoflavonoids by E2-ER-ERE-dependent gene expression in recombinant yeast and MCF-7 human breast cancer cells
    • Lin, C.C., Lu, Y.P., Liu, Y.R., Ho, C.T., Newmark, H, Singletary, K., MacDonald, C., and Huang, M.T. (2001) Inhibition by dietary dibenzoylmethane mammary gland proliferation, formation of DMBA-DNA adducts in mammary glands, and mammary tumorigenesis in Sencar mice. Cancer Lett. 168, 125-132. (SCI)
    • Lin, C.C., Ho, C.T., and Huang, M.T. (2001) Mechanistic studies on the inhibitory action of dietary dibenzoylmethane, a -diketone analogue of curcumin, on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Proceedings of the National Science Council, R.O.C. Part B: Life Science, Vol. 25, No. 3, July, 158-165. (*corresponding author)
    • Tsai, Y.L., Tseng, S.F., Chang, S.H., Lin, C.C., and Teng, S.C. (2002) Involvement of replicative polymerases Tellp, Meclp, Cdc13p, and the ku complex in telomere-telomere recombination. Mol. Cell. Biol. 22, 5679-5687. (SCI)
    • Teng, S.C., Tsai, H.J, Tsai, M.C, Lee, W.M., Chen, I.C., and *Lin, C.C. (2003) Using both chemical and biological fingerprints for the quality study of estrogenic licorice (Glycyrrhiza uralensis). J. Food Sci. 68, 2372-2377. (*corresponding author) (SCI)
    • Lin, C.Y., Chang, H.H., Wu, K.J., Tseng, S.F., Lin, C.C., Lin, C.P. and Teng, S.C. (2005) Extrachromosomal telomeric circles contribute to Rad52, Rad50 and Pol mediated telomere-telomere recombination in Saccharomyces cerevisiae. Eukaryot. Cell 4, 327-336. (SCI)
    • Chen, H.C., Lin, H.Y., Lin, C.C. and Lee, M.H. The encapsulation of curcumin in micelles. Bioengineering Conference, 2005. Proceedings of the IEEE 31st Annual Northeast April 2-3, 2005 Page(s):275 – 276 (EI)
    • Lin, C.C., Wei, G.J., Huang, M.T. and Ho, C.T. (2005) Metabolic pathway of dibenzoylmethane, a -diketone analogue of curcumin, by NADPH-dependent cytochrome P450 enzymes in mouse liver microsomes. J. Food. Drug Anal. 13, 284-288. (SCI)
    • Lin, C.C., Tsai, Y.L., Huang, M.T., Lu, Y.P., Ho, C.T., Tseng, S.F. and Teng, S.C. (2006) Inhibition of estradiol-induced mammary proliferation by dibenzoylmethane through the E2-ER-ERE-dependent pathway. Carcinogenesis 27, 131-136. (SCI) (Impact factor: 5.108; Ranking: 19/123) (NSC 94-231-157-002)
    • Wen, W.Y., Tsai, H.J., Lin, C.C., Tseng, S.F., Wong, C.W. and Teng, S.C. (2006) Telomere configuration influences the choice of telomere maintenance pathways. Biochem. Biophys. Res. Commun. 343: 459-466. (SCI)
    • Lee, M.H. and *Lin, C.C. (2007) Comparison of techniques for extraction of isoflavones from the root of Radix Puerariae: Ultrasonic and Pressurized Solvent Extractions. Food Chem. 105: 223-228. (*corresponding author) (SCI)
    • Lin, C.C., Tsai, Y.L., Ho, C.T. and Teng, S.C. (2008) Determination of the differential estrogenicity of isoflaovnoids by E2-ER-ERE-dependent gene expression in recombinant yeast and MCF-7 human breast cancer cells.. Food Chem. 108:719-726. (SCI))
    • Lin, C.C., Lin, H.Y., Chen, H.C., Yu. M.W. and Lee, M.H. (2009) Stability and characterisation of phospholipid-based curcumin-encapsulated microemulsions Food Chem. 116: 923-928. (SCI)
    • Lee, M.H., Yu, M.W., Kao, L. and *Lin, C.C. (2009) Enhancement of the encapsulation and transmembrane permeation of isoflavone-containing red clover extracts in phospholipid-based microemulsions using different extraction processes. J. Agri. Food Chem. 57: 9489-9495. (*corresponding author) (SCI)
    • Lin, C.C., Huang, M.T. and Ho, C.T. (2010) Dietary dibenzoylmethane altered adipose mass, serum lipid and sex steroid hormone in female mice. J. Food. Drug Anal. 18(5): 339-345. (*corresponding author) (SCI)
    • Lin, C.C., Liu, Y. Huang, Ho, C.T. and M.T. (2011)Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, b-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin. Food & Funct. 2 (1): 78 – 83. (*corresponding author) (SCI)
    • Lee, M.H., Kao, L. and *Lin, C.C. (2011)Comparison of the antioxidant and transmembrane permeative activities of the different polygonum cuspidatum extracts in phospholipid-based microemulsions. J. Agri. Food Chem. 59: 9135-9141. (*corresponding author) (SCI)
    • Lee, M.H., Thomas, J.L., Wang, H.Y., Chang, C.C., Lin, C.C. and Lin, H.Y. (2012) Extraction of resveratrol from polygonum cuspidatum with magnetic orcinol-imprinted poly(ethylene-co-vinyl alcohol) composite particles and their in vitro suppression of human osteogenic sarcoma (HOS) cell line. J. Mater. Chem. 22: 24644-24651. (SCI)
    • Shyu, Y.S., Lu, T.C and *Lin, C.C. (2014) Functional analysis of unfermented and fermented citrus peels and physical properties of citrus peel-added doughs for bread making J. Food Sci. Technol. 51:3803-3811 (SCI)
    • Lin, C.C., Lin, H.Y., Chi, M.H., Shen, C.M. Chen, H.W., Yang, W.J. and Lee, M.H. (2014) Preparation of curcumin microemulsions with food-grade soybean oil/lecithin and their cytotoxicity on the HepG2 cell line. Food Chem. 154: 282-290. (SCI)
    • Hsieh, M.H., Tsai, C.H., Lin, C.C., Li, T.K., Hung, T.W., Chang, L.T., Hsin, L.W. and Teng, S.C. (2015) Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. Cell Mol. Life Sci. 72: 1825-1837. (SCI)
    • Jao, W.C. and Lin, C.C. (2016) Preparation and characterization of Polygonum cuspidatum extract loaded silk fibroin/chitosan electrospun nanofibers. J. China Univ. Sci. Tech. 68: 105-118. (NSC 100--2632-B-157- 001-MY3)
    • Lin, C.C., Hsieh, M.H. and Teng, S.C. (2017) Genistein suppresses the proliferation of telomerase- negative cells. Food Sci. Nutr 5(2): 197-204. (SCI)
    • Lin, C.C. and Lin, Q.R. (2017) Using Combination of Processing Techniques to Optimize the Extraction of Functional Components in Citrus (Citrus Reticulate) Peels.. Intl. J. Agri. Inov. Res. 6(2): 384-390.
    • Jao, W.C. and Lin, C.C. (2017) Evaluation of silk fibroin nanofiber mats containing curcumin for biocompatibility. J. China Univ. Sci. Tech. 72: 15-29. (NSC 100--2632-B-157- 001-MY3)
    • Lin, C.C., Wang, C.C. and Liu, M.H. (2020) Evaluation of the phytoestrogenic activity of Glycine tomentella extracts by different cellular models J. China Univ. Sci. Tech. 79: 135-152. (MOST 105-2320-B-157-001)

    研討會論文
    • EFFECTS OF DIBENZOYLMETHANE STRUCTURAL ANALOGUES ON THE ALTERNATIVE RECOMBINATION PATHWAY FOR TELOMERE LENGTHENING
    • Inhibitory effect of genistein on alternative lengthening of telomere pathway in yeast and mammalian cancer cells
    • 發酵前後柑橘果皮在烘培產品上應用之探討
    • Lin, C.C., Lu, Y.P., Liu, Y.R., Singletary, K., MacDonald, C., Ho, C.T., Newmark, H, and Huang, M.T. In vivo inhibition of mammary carcinogenesis, formation of DNA-carcinogen adducts, mammary gland proliferation by dietary dibenzoylmethane. (2001) The 221st Annual Meeting of American Chemical Society, San Diego, CA, USA.
    • Lin, C.C., Tsai, Y.L., Huang, M.T., Lu, Y.P. and Teng, S.C. Inhibition of dibenzoylmethane on estradiol-induced mammary gland proliferation in Sencar mice and on expression of E2-ERE-dependent oncogenes in MCF-7 cells. (2005) The 229th Annual Meeting of American Chemical Society, San Diego, CA, USA.
    • Lee, M.H. and Lin, C.C. Enhancement of extraction yield of isoflavonoids from Puerariae powders using ultrasonic technique. (2005) The 229th Annual Meeting of American Chemical Society, San Diego, CA, USA.
    • 林娟娟. Chemoprevention by phytochemicals. (2005) 新世紀的健康、食品與環保研討會,南京農業大學,中國.
    • Lin, C.C., Singletary, K., MacDonald, C., Ho, C.T., Newmark, H, and Huang, M.T. Mechanisms of inhibitory action of dietary dibenzoylmethane (DBM) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis in mice. (2000) Proceedings of the American Association for Cancer Research, 41, 574.
    • Tsai, H.J., Tsai M.C., Lee, W.M., Chen, I.C., and Lin, C.C. Analysis of estrogenic activity in food and natural products with a recombinant yeast assay. (2002) 17th Symposium on Natural products and Biotechnology of Chinese Herbs, Taiwan.
    • Lee, M.H and Lin, C.C. Enhancement of Extraction Yield of Isoflavonoids from Radix Puerariae Powders Using Ultrasonic Technique. (2003) The 12nd International Congress of Oriental Medicine, Taipei.
    • 陳旭志、林宏殷、林娟娟、李玫樺 。微乳膠包覆薑黃素之穩定性研究。2004生物醫學工程科技研討會，台南。
    • Lin, C.C., Lin, C.Y., Chang, H.H., Tseng, S.F., Lin, C.P. and Teng, S.C. Extrachromosomal telomeric circles contribute to Rad52, Rad50 and Polδ mediated telomere-telomere recombination in Saccharomyces cerevisiae. (2005) Keystone symposia conference: Stem cells, Senescence and Cancer, Singapore.
    • 陳旭志、林宏殷、林娟娟、楊立誌、蔡尚伯、李玫樺. 製備超音波感受性的磷脂質微乳液之新載藥劑型.2005醫學工程年會，中壢.
    • Huang, M.T., Liu, Y., Lin, C.C. and Ho, C.T. Inhibitory effects of dibezoylmethane on chemically- and ultraviolet B light-induced inflammation, sunburn carcinogenesis in mice. (2006) The 232nd Annual Meeting of American Chemical Society, San Francisco, CA, USA.
    • Teng, S.C. and Lin, C.C. Effect of genistein on type II alternative lengthening of telomere pathway in yeast (2008) The 236nd Annual Meeting of American Chemical Society, Philadelphia, PA, USA
    • Lin C.C., Lee, M.H. and Yu, M.W. Comparison of the encapsulation amounts of isoflavones-containing red clover extracts in microemulsion system using different extraction techniques (2008) The 236nd Annual Meeting of American Chemical Society, Philadelphia, CA, USA
    • 李宗翰、林嘉姿、李玫樺、林娟娟。虎杖多酚萃取物之微乳膠於經皮穿透功效之研究。2009台灣食品科技學會第39次年會，宜蘭。
    • 葉家安、梁文瑄、歐順華、林娟娟。一條根中抗氧化與雌激素活性成分之研究。2009第四屆新世紀健康、食品與環保研討會，台北。
    • Lin, C.C. Inhibitory effect of genistein on alternative lengthening of telomere pathway in yeast and mammalian cancer cells. (2011) SCBA (Society of Chinese Biomedical Association) Conference, Guangzhou, China.
    • Lin, C.C., Hung, T.W. and Teng, S.C. Isolation of the major phytoestrogenic component from I-Tiao-Gung and its effect on alternative lengthening of telomere pathway in yeast. (2011) International Conference on Food Factors, Taipei, Taiwan.
    • Lin, H.Y., Lin, C.C., Ma, W.C. and Lee, M.H. Preparation Co-Q10 Lipid-Nanoemulsions as an Oral Formulation. (2011) International Conference on Food Factors, Taipei, Taiwan.
    • 王宣云、林宏殷、林娟娟、李玫樺。製備智慧型苔黑素磁性奈米複合微粒萃取虎杖中多酚類活性分子。2012中華民國高分子學會年會，中壢。
    • Lee, M.H., Thomas, J.L., Wang, H.Y., Chang, C.C., Lin, C.C. and Lin, H.Y. Extraction of Resveratrol and in vitro suppression of human osteogenic sarcoma (HOS) cell line with Magnetic Orcinol-imprinted Poly(ethylene-co-vinyl alcohol) Composite Particles", International Conference Molecularly Imprinted Polymers - Science and Technology (MIP 2012), Paris, France.
    • Lin, C.C., Lin, H.Y., Shen, C.M., Chen, H.W., Yang , W.J. and Lee, M.H. Cytotoxicity effects of curcumin- encapsulated soybean oil-based phospholipid microemulsions on the hepatocellular carcinoma cell line. (2013) ISNFF: Functional Foods, Nutraceuticals, Natural Health Products and Dietary Supplements November, Taipei, Taiwan.
    • 林娟娟、劉滿海、王經強。(2014) Evaluation of the phytoestrogenic activity of I-Tiao-Gung from Taiwan market by different cellular models. 2014食品科技學會第44次年會，高雄
    • Lin, C.C. Study of a TOP2 inhibitor to prevent cell proliferation in ALT-type cancer cells. Anticancer drug action and drug resistance: from cancer biology to the clinic (EACR-AACR-SIC Special Conference 2015), Florence, Italy. (MOST 103-2313-B-157- 003)
    • 林娟娟、林昱文、林千茹、高大佑。以超音波萃取發酵前後柑橘皮粉末中機能性成分之比較。2015食品科技學會第45次年會，台北
    • Lin, C.C., Hsieh, M.H. EFFECTS OF DIBENZOYLMETHANE STRUCTURAL ANALOGUES ON THE ALTERNATIVE RECOMBINATION PATHWAY FOR TELOMERE LENGTHENING.. IARC 50th Anniversary Conference, June6-10, 2016, Lyon, France. (MOST 104-2320-B-157-001)
    • Lin, C.C. USING COMBINATION OF DIFFERENT OPERATING PROCESSSES TO ENHANCE THE EXTRACTION OF FUNCTIONAL COMPONENTS FROM CITRUS PEELS (CITRUS RETICULATE). The 11th World Congress on Polyphenols Applications, June 20-21, 2017, Vienna, Austria. (MOST 105-2320-B-157-001)
    • 林娟娟、江東益、林千茹、劉滿海、李玫樺。以天然素材建構之微乳膠包覆異黃酮的研究。2017食品科技學會第47次年會，高雄
    • Chuang, C.C., Lin, C.C., Liou, B.K. and Chen, Y.D. Effect of puffing conditions on physical properties and antioxidant activities of Djulis and quinoa. 2018穀類食品產業國際研討會，台北
    • 程耀凱、劉秉華、陳郁丹、莊朝琪、林娟娟。以不同膨發條件處理之台灣藜麥萃取液中芸香苷與槲皮素含量比較2018食品科技學會第48次年會，台北

    專書論文
    • 第四屆新世紀健康食品與環保研討會論文集
    • Dietary Supplements(Chapter 19: Chemopreventive effects of dibenzoylmethane on mammary tumorigenesis
    • Lin, C.C. Mechanistic studies on the inhibitory action of dietary dibenzoylmethane, a -diketone analogue of curcumin, on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. (2001) Ph.D. thesis, Rutgers University Press.
    • Lin, C.C., Lu, Y.P., Liu, Y.R., Singletary, K., MacDonald, C., Ho, C.T., Newmark, H, and Huang, M.T. (2003) In vivo inhibition of mammary carcinogenesis, formation of DNA-carcinogen adducts, mammary gland proliferation by dietary dibenzoylmethane. In “Food Factors for Health Promotion and Disease Prevention”, ACS symposium series 851, American Chemical Society, pp 178-195.
    • Lin, C.C., Ho, C.T. and Huang, M.T. (2008) Chemopreventive Effects of Dibenzoylmethane on Mammary Tumorigenesis. In “Dietary Supplements”, ACS symposium series 987, American Chemical Society, pp 281-292.

    專利及技轉:
    • 含薑黃素之奈米纖維膜敷料
    • 具虎杖多酚萃取物之聚丙烯腈奈米纖維電紡膜結構
    • 具一條根萃取物微乳膠結構之裝置
    • 含薑黃素之奈米纖維膜敷料 (發明人:饒文娟,林娟娟; 新型第M422970號)
    • 具虎杖多酚萃取物之聚丙烯腈奈米纖維電紡膜結構 (發明人:林娟娟; 新型第M477200號)
    • 具一條根萃取物微乳膠結構之裝置(發明人:林娟娟、李玫樺; 新型第M504611號)
    • 保養品裝置 (發明人:林娟娟; 新型第535217號)
    • 虎仗多酚萃取物之製造方法(99年技轉案；悅華科技股份有限公司)
    • 具生物活性異黃酮的製造(107年技轉案；悅華科技股份有限公司)

    研究計畫或建教合作案：


    計畫名稱 合作廠商 期間 備註
    多頻率超音波應用於茶微膠囊控釋之研究 產學計畫
    (明綸科技有限公司)    		 2020/4/1-2021/3/31 計畫主持人
    養生藥膳雞的製作與食用前後體質檢測之研究 產學計畫
    (上醫健康事業股份有限公司)    		 2019/2/1-2020/1/31 計畫主持人
    廢棄食材以生物轉化法製備機能性多酚的評估與開發 學界協助中小企業科技關懷 2019/6-2019/11 計畫主持人
    以生物轉換法製備植物活性多酚及應用於保健產品開發 產學計畫
    (悅華科技股份有限公司)    		 2017/12/1-2018/9/30 計畫主持人
    銀髮保健技術跨域整合輔導計劃 (106年度學界協助中小企業科技關懷跨域整合計畫) 經濟部 2017/6-2017/11 子計畫主持人
    以天然素材建構新穎性微乳膠包覆植物雌激素之活性評估 (MOST 105-2320-B-157-001) 科技部 2016/8-2017/7 計畫主持人
    養生保健食品之開發與技術輔導 (105年度學界協助中小企業科技關懷跨域整合計畫) 經濟部 2016/6-2016/11 子計畫主持人
    以天然素材建構新穎性微乳膠包覆植物雌激素之活性評估 (MOST 104-2320-B-157-001) 科技部 2015/8-2016/7 計畫主持人
    微乳化薑黃素b-diketone衍生物抑制以端粒重組機制生存細胞之研究 (MOST 103-2313- B-157-003) 科技部 2014/8-2015/7 計畫主持人
    健康食品之創新研發與技術輔導 (103年度學界協助中小企業科技關懷計畫) 經濟部 2014/6-2014/11 子計畫主持人
    生技藥妝品新穎活性成分開發、篩選與安全性評估-防曬藥妝品新穎活性成分設計合成與篩-子計畫:新穎性高分子材料包覆多酚類天然藥物之功效及安全性研究 (NSC 100-2632-B-157-001-MY3) 國科會
    (提升私校研發能量專案計畫)    		 2011/8-2014/7 子計畫主持人
    台灣產橄欖酒製程中多酚含量及抗氧化活性變化之研究 (華食科101產學字009號) 產學計畫
    (晶采興業股份有限公司)    		 2012/12-2013/1 計畫主持人
    Genistein對端粒重組機制生存之癌細胞增生的影響 (NSC 97-2313-B-157-001-MY3) 國科會 2008/8-2011/7 計畫主持人
    虎仗多酚萃取物之功效評估及應用於保養品配方最適化研究 教育部園區產學計畫 2010/1-2010/12 計畫主持人
    以多酚含量及抗氧化活性檢測作為蔬果酵素產品品質標準化之研究 產學計畫
    (伍鑫酵素)    		 2008/1-2009/1 共同主持人
    異黃酮對端粒重組機制生存之癌細胞增生的影響 (NSC 96-2313-B-157-003-) 國科會 2007/8-2008/7 計畫主持人
    一條根中有效植物雌激素影響E2—ER-ERE途徑誘發之體內外乳腺細胞增生機制之研究 (NSC 95-2313-B-157-002-) 國科會 2006/8-2007/7 計畫主持人
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